1-2 In Ch. 16, Jesus reveals to his disciples what they must know to prepare them for their coming mission. He links it with the preceding section of his final discourse by sharpening the warning he has already given them concerning the hatred of the world (John 15:18-27). He applies this revelation particularly to their local conditions and predicts that they will suffer excommunication from the synagogue and even death (cf. the blind man in 9:22, 34; Lazarus in 12:10). While Jesus was with the disciples, he could shelter and direct them. They must realize, however, that even his resurrection will not be sufficient to convince his enemies to remove the hatred that exists between them and Jesus' followers.
3 Jesus attributes the action of his foes to ignorance-not the ignorance of intellectual knowledge, but the lack of a personal experience of God and Christ (15:21-22). Their attitude is determined by who they think Jesus is and by who they think God is, rather than by actual contact with either. So warped has the attitude become that their contact with Jesus has generated hate for both himself and the Father (15:24; cf. Matt. 6:23).
4 It may well be that this particular utterance of Jesus was reported by John because of the pressing need for courage in the church of his day. The Apocalypse indicates a wide break between the church and the synagogue at the end of the first century (Rev. 2:9; 3:9; those who professed faith in Jesus were completely disowned by their Jewish compatriots.
[NIV BIBLE COMMENTARY Volume 2: New Testament].
16:2 They will put you out of the synagogues . . . kills you: The persecution that the disciples would face included excommunication and even execution. Excommunication had economic as well as religious implications, because much of the life of an ancient Jew revolved around the synagogue. Offers express the idea of offering a sacrifice. The murderers of believers would imagine that they were offering a sacrifice to God.
[THE NKJV STUDY BIBLE Second Edition].
JESUS IS LORD.